Transmembrane Lipid Migration in Planar Asymmetric Bilayer Membranes

Compositional interface dynamics within symmetric and asymmetric planar lipid bilayer membranes

Formation of planar bilayer membranes from lipid monolayers. A critique.

The formation of planar bilayer membranes from lipid monolayers as described by Montal and Mueller (Proc. Natl. Acad. Sci. 1972. 69:3561) is analyzed. Bilayers absolutely free of alkane solvents or other nonpolar hydrocarbons can be formed on polytetrafluoroethylene (PTFE) (e.g. Teflon) septa only if certain boundary conditions are satisfied. Measurements have been made of the contact angles be...

The nonelectrolyte permeability of planar lipid bilayer membranes

The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton's rule. The is, Pd alpha DKhc, where/Pd is the permeability coefficient of a solute through the bilayer, Khc is its hydrocarbon:water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative m...

Chloride Transport in Porous Lipid Bilayer Membranes

This paper describes dissipative Cl(-) transport in "porous" lipid bilayer membranes, i.e., cholesterol-containing membranes exposed to 1-3 x 10(-7) M amphotericin B. P(DCl) (cm.s(-1)), the diffusional permeability coefficient for Cl(-), estimated from unidirectional (36)Cl(-) fluxes at zero volume flow, varied linearly with the membrane conductance (Gm, ohm(-1).cm(-2)) when the contributions o...

Hydrodynamic effects on spinodal decomposition kinetics in planar lipid bilayer membranes.

The formation and dynamics of spatially extended compositional domains in multicomponent lipid membranes lie at the heart of many important biological and biophysical phenomena. While the thermodynamic basis for domain formation has been explored extensively in the past, domain growth in the presence of hydrodynamic interactions both within the (effectively) two-dimensional membrane and in the ...